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ASSOCIATE SCIENTIST 

Opportunity​

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We are looking for an Associate Scientist to join our multidisciplinary and dynamic team. This position represents an excellent opportunity for someone looking to contribute to the translation of an early-stage oncolytic virus product through clinical development. The successful applicant will be working in a fast-paced environment and will contribute to strategic research and development goals.

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The candidate must be a proactive, organised individual with hands on wet lab experience. We are looking for someone who has excellent communication skills, can interact with a diverse group of scientific disciplines and is happy to jump in when required in what is an exciting work environment

 

About us

 

​Theolytics is a clinical-stage, oncology biotech with a mission to improve the lives of people impacted by cancer through the development of transformative oncolytic immunotherapies.

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We have pioneered a new approach to develop best-in-class oncolytic immunotherapies suitable for direct and systemic intravenous delivery. The company is focused on the advancement of its lead programme THEO-260 in clinical trials with the ambition of providing better outcomes for patients with stroma-rich solid cancers, for whom current treatment options are limited.

 

THEO-260 is being investigated in two clinical trials for the treatment of women with Platinum-Resistant Ovarian Cancer (PROC), a Phase 1/2a trial called OCTOPOD-IV in the UK, Spain and Canada and OCTOPOD-IP in the US. Additional pipeline programmes in preclinical development include novel candidates developed for colorectal cancer and haematological malignancies, where there remains significant unmet need.

 

Theolytics was founded in 2017, is headquartered in Oxford UK, and is backed by international life sciences investors Taiho Ventures, M Ventures, Oxford Science Enterprises, Epidarex Capital, BGF, Sound Bioventures and Oxford University Innovation. Theolytics has also received competitive grant awards including from Horizon Europe and UK.

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Theolytics is committed to creating, inspiring and protecting a culture of inclusivity and diversity in everything we do. We bring our authentic selves to work, and strive to find and support the best person for any given role within our team. Our recruitment leads with capability, values and performance.​

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Responsibilities

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  • Execution of experiments, collating, analysing and presenting data from a variety of sources;

  • Routine laboratory experiments including, but not limited to:

  • Maintenance of cell culture;

  • Processing of primary tumour material;

  • DNA and RNA extraction;

  • Flow cytometry;

  • Ensuring virus batch quality control;

  • Supporting histology experiments (IF/IHC)

  • Detailed recording of experiment details and processes;

  • Supporting a team of scientists working with various human tumour models, to include the maintenance of quality sample archiving systems;

  • Day-to-day maintenance of the laboratory.

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 We’re looking for someone that has:

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  • A BSc and/or MSc degree in a relevant discipline (such as Virology, Cancer Biology, Molecular and Cell Biology);

  • · Hands on, independent wet lab experience conducted as part or degree or placement project.

  • Recent experience in at least two of the following:

    • Cell culture

    • Primary tumour culture

    • Virology techniques (such as purification, plaque assays and TCID50)

    • Molecular and/or Biochemical techniques (such as bacterial cell culture, cloning, PCR, ELISA and flow cytometry)

  • Strong IT skills (including proficiency with Word, Excel and PowerPoint), and comfort using shared drives.

  • Strong communicator

  • Adaptable

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It would be useful if you have:

 

  • Pharmaceutical and/or biotech industry placement experience (will put candidates at a significant advantage);

  • Experience processing patient tumour samples;

  • Experience working with viruses;

  • Technical experience on qPCR, RNA/DNA extractions, and some cell-based assays;

  • Experience in IHC / IF;

  • Experience following SOPs;

  • Detail oriented and meticulous, with a dedication to performing high-quality science;

  • A willingness and propensity to take on responsibility.

  • High motivation for, and commitment to, research on anticancer therapies and drug discovery ​​

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Company Benefits: Competitive salary and holiday allowance, flexible working hours, private medical insurance, company socials, ongoing training and workshops and an employer-matched pension scheme.

 

To apply: email careers@theolytics.com with a CV and brief cover letter. 

Please note, we are working with a recruitment partner, STEM recruitment on this recruitment who may contact you on our behalf as part of this process.  

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